Version 5.4
Homo sapiens Gene: KPNA3
Summary
InnateDB Gene IDBG-33878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA3
Gene Name karyopherin alpha 3 (importin alpha 4)
Synonyms hSRP1; IPOA4; SRP1; SRP1gamma; SRP4
Species Homo sapiens
Ensembl Gene ENSG00000102753
Encoded Proteins
IDBP-33880
karyopherin alpha 3 (importin alpha 4)
IDBP-368515
karyopherin alpha 3 (importin alpha 4)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:49699307-49792921
Strand Reverse strand
Band q14.2
Transcripts
ENST00000261667 ENSP00000261667
ENST00000436760 ENSP00000393869
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 50 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008139 nuclear localization sequence binding
GO:0008565 protein transporter activity
Biological Process
GO:0006461 protein complex assembly
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0019221 cytokine-mediated signaling pathway
GO:0046718 viral entry into host cell
GO:0075732 viral penetration into host nucleus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021929
View Gene Order
ENSBTAG00000004850
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.527919 Hs.733349
RefSeq NM_002267
HUGO
OMIM
CCDS CCDS9421
HPRD 03536
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca