Mus musculus Gene: Gpd2
Summary
InnateDB Gene IDBG-171625.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpd2
Gene Name glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms AA408484; AI448216; AU021455; AW494132; Gdm1; Gpd-m; GPDH; Gpdh-m; TISP38;
Species Mus musculus
Ensembl Gene ENSMUSG00000026827
Encoded Proteins
glycerol phosphate dehydrogenase 2, mitochondrial
glycerol phosphate dehydrogenase 2, mitochondrial
glycerol phosphate dehydrogenase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115159:
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:57237635-57370719
Strand Forward strand
Band C1.1
Transcripts
ENSMUST00000028167 ENSMUSP00000028167
ENSMUST00000112618 ENSMUSP00000108237
ENSMUST00000141536
ENSMUST00000148991
ENSMUST00000124689
ENSMUST00000154612
ENSMUST00000169687 ENSMUSP00000130992
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004368 glycerol-3-phosphate dehydrogenase activity
GO:0005509 calcium ion binding
GO:0016491 oxidoreductase activity
GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
Biological Process
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0019563 glycerol catabolic process
GO:0035264 multicellular organism growth
GO:0043010 camera-type eye development
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0009331 glycerol-3-phosphate dehydrogenase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
KEGG
Glycerophospholipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q64521
TrEMBL
UniProt Splice Variant
Entrez Gene 14571
UniGene Mm.3711 Mm.400337 Mm.416060
RefSeq NM_001145820 NM_010274
OMIM
CCDS CCDS16045
HPRD
IMGT
MGI ID MGI:99778
MGI Symbol Gpd2
EMBL AB045714 AH009802 AK034353 AK144716 AK149851 AK167152 BC021359 D50430 U60987
GenPept AAB50545 AAG12342 AAH21359 BAA08926 BAB97201 BAC28685 BAE26028 BAE29123 BAE39294
RNA Seq Atlas 14571