Version 5.4
Mus musculus Gene: Pdgfra
Summary
InnateDB Gene IDBG-171929.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pdgfra
Gene Name platelet derived growth factor receptor, alpha polypeptide
Synonyms AI115593; CD140a; Pdgfr-2
Species Mus musculus
Ensembl Gene ENSMUSG00000029231
Encoded Proteins
IDBP-171931
platelet derived growth factor receptor, alpha polypeptide
IDBP-622507
platelet derived growth factor receptor, alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134853:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:75152291-75198204
Strand Forward strand
Band C3.3
Transcripts
ENSMUST00000000476 ENSMUSP00000000476
ENSMUST00000168162 ENSMUSP00000127173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001553 luteinization
GO:0001701 in utero embryonic development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008210 estrogen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008585 female gonad development
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0010544 negative regulation of platelet activation
GO:0010863 positive regulation of phospholipase C activity
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030539 male genitalia development
GO:0033327 Leydig cell differentiation
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045740 positive regulation of DNA replication
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0050920 regulation of chemotaxis
GO:0055003 cardiac myofibril assembly
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071230 cellular response to amino acid stimulus
GO:0072277 metanephric glomerular capillary formation
GO:2000739 regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031226 intrinsic component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134853
View Gene Order
ENSBTAG00000007173
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04020
Calcium signaling pathway pathway
mmu04540
Gap junction pathway
mmu05218
Melanoma pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu05214
Glioma pathway
mmu05215
Prostate cancer pathway
mmu04510
Focal adhesion pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04540
Gap junction pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04020
Calcium signaling pathway pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
atf2_pathway
ATF-2 transcription factor network
pdgf_pathway
PDGF receptor signaling network
pdgfrapathway
PDGFR-alpha signaling pathway
Cross-References
SwissProt P26618
TrEMBL Q06BS2
UniProt Splice Variant
Entrez Gene 18595
UniGene Mm.221403 Mm.431687
RefSeq NM_001083316 NM_011058 XM_006504261 XM_006504262 XM_006504263
OMIM
CCDS CCDS19351
HPRD
IMGT
MGI ID MGI:97530
MGI Symbol Pdgfra
EMBL AK081664 AK136490 AK147267 AK163952 BC053036 DQ912857 M57683 M84607
GenPept AAA39733 AAA39904 AAH53036 ABI96988 BAC38283 BAE23004 BAE27808 BAE37548
RNA Seq Atlas 18595

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca