Homo sapiens Gene: PDGFRA
Summary
InnateDB Gene IDBG-18854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFRA
Gene Name platelet-derived growth factor receptor, alpha polypeptide
Synonyms CD140A; PDGFR-2; PDGFR2; RHEPDGFRA;
Species Homo sapiens
Ensembl Gene ENSG00000134853
Encoded Proteins
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, alpha polypeptide
platelet-derived growth factor receptor, alpha polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:54229097-54298247
Strand Forward strand
Band q12
Transcripts
ENST00000257290 ENSP00000257290
ENST00000508170 ENSP00000425648
ENST00000509092
ENST00000512143 ENSP00000425626
ENST00000509490 ENSP00000424218
ENST00000503856 ENSP00000425902
ENST00000504461 ENSP00000426472
ENST00000512522 ENSP00000425232
ENST00000461294
ENST00000507536
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005018 platelet-derived growth factor alpha-receptor activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0038085 vascular endothelial growth factor binding
GO:0042803 protein homodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001553 luteinization
GO:0001701 in utero embryonic development
GO:0001775 cell activation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008210 estrogen metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008585 female gonad development
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0010544 negative regulation of platelet activation
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030198 extracellular matrix organization
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030539 male genitalia development
GO:0033327 Leydig cell differentiation
GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045740 positive regulation of DNA replication
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048557 embryonic digestive tract morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0050920 regulation of chemotaxis
GO:0055003 cardiac myofibril assembly
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071230 cellular response to amino acid stimulus
GO:0072277 metanephric glomerular capillary formation
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000739 regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031226 intrinsic component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
Calcium signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Focal adhesion pathway
Gap junction pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
INOH
PDGF signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Phospholipids as signalling intermediaries [Biocarta view]
Pdgf signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
PID NCI
ATF-2 transcription factor network
PDGF receptor signaling network
PDGFR-alpha signaling pathway
Cross-References
SwissProt P16234
TrEMBL D6RDX0 D6RG11 D6RIG5
UniProt Splice Variant
Entrez Gene 5156
UniGene Hs.609382 Hs.74615
RefSeq NM_006206 XM_005265743 XM_006714039 XM_006714040
HUGO HGNC:8803
OMIM 173490
CCDS CCDS3495
HPRD 01429
IMGT
EMBL AC098587 AC138779 AK316578 AY229892 BC015186 BC063414 D50017 M21574 M22734
GenPept AAA60048 AAA96715 AAH15186 AAH63414 AAP69563 BAA08742 BAG38166
RNA Seq Atlas 5156