Version 5.4
Mus musculus Gene: Magoh
Summary
InnateDB Gene IDBG-171992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Magoh
Gene Name mago-nashi homolog, proliferation-associated (Drosophila)
Synonyms Mago-m; Mos2
Species Mus musculus
Ensembl Gene ENSMUSG00000028609
Encoded Proteins
IDBP-171994
mago-nashi homolog, proliferation-associated (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162385:
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:107879755-107887424
Strand Forward strand
Band C7
Transcripts
ENSMUST00000030348 ENSMUSP00000030348
ENSMUST00000141376
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 165 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 7 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 165 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006417 regulation of translation
GO:0007292 female gamete generation
GO:0008150 biological_process
GO:0008380 RNA splicing
GO:0051028 mRNA transport
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162385
View Gene Order
ENSBTAG00000003485
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_198522
Nonsense-Mediated Decay (NMD) pathway
REACT_198528
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_232353
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224602
Transport of Mature Transcript to Cytoplasm pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_225310
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_226022
Gene Expression pathway
REACT_220982
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_222777
Nonsense-Mediated Decay (NMD) pathway
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt P61327
TrEMBL G3UZW7
UniProt Splice Variant
Entrez Gene 66441
UniGene Mm.395180 Mm.474588
RefSeq NM_001282737 NM_010760
OMIM
CCDS CCDS18441
HPRD
IMGT
MGI ID MGI:1330312
MGI Symbol Magoh
EMBL AC148326 AF007862 AF035939 AK011512 AL611936 BC018176 CH466527
GenPept AAB66722 AAC40044 AAH18176 BAB27668 CAM23583 EDL30768
RNA Seq Atlas 17149 66441

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca