Homo sapiens Gene: MAGOH
Summary
InnateDB Gene IDBG-98726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAGOH
Gene Name mago-nashi homolog, proliferation-associated (Drosophila)
Synonyms MAGOH1; MAGOHA;
Species Homo sapiens
Ensembl Gene ENSG00000162385
Encoded Proteins
mago-nashi homolog, proliferation-associated (Drosophila)
mago-nashi homolog, proliferation-associated (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:53226892-53238610
Strand Reverse strand
Band p32.3
Transcripts
ENST00000371470 ENSP00000360525
ENST00000371466 ENSP00000360521
ENST00000495868
ENST00000462941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 202 experimentally validated interaction(s) in this database.
Experimentally validated
Total 202 [view]
Protein-Protein 198 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
mRNA 3'-end processing pathway
Nonsense-Mediated Decay (NMD) pathway
RNA Polymerase II Transcription Termination pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
mRNA Splicing pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
RNA transport pathway
mRNA surveillance pathway pathway
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P61326
TrEMBL B1ARP8 F5H6P7
UniProt Splice Variant
Entrez Gene 55110
UniGene
RefSeq NM_002370
HUGO HGNC:6815
OMIM 602603
CCDS CCDS577
HPRD
IMGT
EMBL AC021049 AF035940 AF067173 AK297895 AK312113 AL606760 BC018211 CH471059
GenPept AAC39606 AAD32457 AAH18211 BAG35049 BAG60216 CAI18914 EAX06747 EAX06748
RNA Seq Atlas 4116 55110