Version 5.4
| Mus musculus Gene: Polr2e | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-172399.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Polr2e | ||||||||||||||||||||||
| Gene Name | polymerase (RNA) II (DNA directed) polypeptide E | ||||||||||||||||||||||
| Synonyms | 2410021N14Rik; 25kDa; AW208866; RPB5; XAP4 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000004667 | ||||||||||||||||||||||
| Encoded Proteins |
polymerase (RNA) II (DNA directed) polypeptide E
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099817:
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 10:80035949-80039795 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | C1 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
Transcription-coupled NER (TC-NER) pathway
Innate Immune System pathway
RNA Polymerase I Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Formation of the Early Elongation Complex pathway
mRNA Splicing pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase II Transcription Initiation pathway
mRNA Splicing - Minor Pathway pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase I Transcription Termination pathway
Immune System pathway
Nucleotide Excision Repair pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
DNA Repair pathway
Transcriptional regulation by small RNAs pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Pre-transcription Events pathway
Cytosolic sensors of pathogen-associated DNA pathway
mRNA Capping pathway
Gene Expression pathway
Regulatory RNA pathways pathway
RNA Polymerase III Transcription Termination pathway
mRNA Splicing - Major Pathway pathway
RNA Polymerase I Promoter Escape pathway
Dual incision reaction in TC-NER pathway
RNA Polymerase I Promoter Clearance pathway
RNA Polymerase I Chain Elongation pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
RNA Polymerase III Transcription pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase III Chain Elongation pathway
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| KEGG |
Pyrimidine metabolism pathway
RNA polymerase pathway
Purine metabolism pathway
Huntington's disease pathway
Cytosolic DNA-sensing pathway pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Tat-mediated HIV elongation arrest and recovery pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Viral Messenger RNA Synthesis pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase III Transcription Termination pathway
RNA Polymerase III Chain Elongation pathway
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase I Transcription Initiation pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Capping pathway
MicroRNA (miRNA) biogenesis pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
HIV Transcription Initiation pathway
Pausing and recovery of HIV elongation pathway
RNA Polymerase II HIV Promoter Escape pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
HIV elongation arrest and recovery pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Influenza Infection pathway
RNA Polymerase I Transcription pathway
RNA Polymerase III Transcription Initiation pathway
Innate Immune System pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
Influenza Viral RNA Transcription and Replication pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
Immune System pathway
HIV Life Cycle pathway
RNA Polymerase III Transcription pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Influenza Life Cycle pathway
mRNA Splicing pathway
Cytosolic sensors of pathogen-associated DNA pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
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| KEGG |
Pyrimidine metabolism pathway
Purine metabolism pathway
RNA polymerase pathway
Huntington's disease pathway
Cytosolic DNA-sensing pathway pathway
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| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.18579 | ||||||||||||||||||||||
| RefSeq | NM_025554 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS35972 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||