Version 5.4
| Homo sapiens Gene: POLR2E | |||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-13793.6 | ||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
| Gene Symbol | POLR2E | ||||||||||||||||||||||||||||||||||||||
| Gene Name | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa | ||||||||||||||||||||||||||||||||||||||
| Synonyms | hRPB25; hsRPB5; RPABC1; RPB5; XAP4 | ||||||||||||||||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSG00000099817 | ||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||
| Summary |
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 19:1086579-1095380 | ||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||
| Band | p13.3 | ||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||
| REACTOME |
Tat-mediated HIV elongation arrest and recovery pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
Viral Messenger RNA Synthesis pathway
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase III Transcription Termination pathway
RNA Polymerase III Chain Elongation pathway
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Promoter Escape pathway
RNA Polymerase I Transcription Initiation pathway
mRNA Splicing - Major Pathway pathway
mRNA Splicing - Minor Pathway pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
mRNA Capping pathway
MicroRNA (miRNA) biogenesis pathway
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Promoter Escape pathway
RNA Polymerase II Transcription Initiation pathway
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
HIV Transcription Initiation pathway
Pausing and recovery of HIV elongation pathway
RNA Polymerase II HIV Promoter Escape pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
RNA Pol II CTD phosphorylation and interaction with CE pathway
HIV elongation arrest and recovery pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
Formation of transcription-coupled NER (TC-NER) repair complex pathway
Dual incision reaction in TC-NER pathway
Transcription-coupled NER (TC-NER) pathway
Influenza Infection pathway
RNA Polymerase I Transcription pathway
RNA Polymerase III Transcription Initiation pathway
Innate Immune System pathway
Transcriptional regulation by small RNAs pathway
Epigenetic regulation of gene expression pathway
Influenza Viral RNA Transcription and Replication pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
Immune System pathway
HIV Life Cycle pathway
RNA Polymerase III Transcription pathway
HIV Infection pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Influenza Life Cycle pathway
mRNA Splicing pathway
Cytosolic sensors of pathogen-associated DNA pathway
Nucleotide Excision Repair pathway
Gene Expression pathway
Disease pathway
DNA Repair pathway
Negative epigenetic regulation of rRNA expression pathway
Regulatory RNA pathways pathway
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| KEGG |
Pyrimidine metabolism pathway
Purine metabolism pathway
RNA polymerase pathway
Huntington's disease pathway
Cytosolic DNA-sensing pathway pathway
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| INOH | |||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||||
| SwissProt | P19388 | ||||||||||||||||||||||||||||||||||||||
| TrEMBL | B4DJ89 E5KT65 K7EJ87 K7EQN2 | ||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 5434 | ||||||||||||||||||||||||||||||||||||||
| UniGene | Hs.737181 | ||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_002695 XM_005259579 | ||||||||||||||||||||||||||||||||||||||
| HUGO | HGNC:9192 | ||||||||||||||||||||||||||||||||||||||
| OMIM | 180664 | ||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS12056 | ||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||
| EMBL | AC004151 AK295975 AK312625 BC004441 BC034144 CH471139 D38251 HQ206186 HQ206187 HQ206188 HQ206189 HQ206190 HQ206191 HQ206192 HQ206193 HQ206194 HQ206195 HQ206196 HQ206197 HQ206198 HQ206199 HQ206200 HQ206201 HQ206202 HQ206203 HQ206204 HQ206205 HQ206206 HQ206207 HQ206208 HQ206209 HQ206210 HQ206211 HQ206212 HQ206213 HQ206214 HQ206215 HQ206216 HQ206217 HQ206218 HQ206219 HQ206220 HQ206221 HQ206222 HQ206223 HQ206224 HQ206225 J04965 S42643 | ||||||||||||||||||||||||||||||||||||||
| GenPept | AAA62401 AAB19339 AAC03238 AAH04441 AAH34144 ADP92094 ADP92095 ADP92096 ADP92097 ADP92098 ADP92099 ADP92100 ADP92101 ADP92102 ADP92103 ADP92104 ADP92105 ADP92106 ADP92107 ADP92108 ADP92109 ADP92110 ADP92111 ADP92112 ADP92113 ADP92114 ADP92115 ADP92116 ADP92117 ADP92118 ADP92119 ADP92120 ADP92121 ADP92122 ADP92123 ADP92124 ADP92125 ADP92126 ADP92127 ADP92128 ADP92129 ADP92130 ADP92131 ADP92132 ADP92133 BAA07406 BAG35511 BAG58751 EAW69548 EAW69549 EAW69550 | ||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 5434 | ||||||||||||||||||||||||||||||||||||||