Version 5.4
Mus musculus Gene: Il3
Summary
InnateDB Gene IDBG-172892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il3
Gene Name interleukin 3
Synonyms BPA; Csfmu; HCGF; Il-3; MCGF; PSF
Species Mus musculus
Ensembl Gene ENSMUSG00000018914
Encoded Proteins
IDBP-172894
interleukin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:54265303-54267277
Strand Reverse strand
Band B1.3
Transcripts
ENSMUST00000019058 ENSMUSP00000019058
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005135 interleukin-3 receptor binding
GO:0008083 growth factor activity
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0006110 regulation of glycolytic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0033026 negative regulation of mast cell apoptotic process
GO:0033028 myeloid cell apoptotic process
GO:0035304 regulation of protein dephosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668 positive regulation of mast cell proliferation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04210
Apoptosis pathway
mmu05310
Asthma pathway
INOH
INOH website
IL-3 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P01586
TrEMBL Q5SX77
UniProt Splice Variant
Entrez Gene 16187
UniGene Mm.983
RefSeq NM_010556
OMIM
CCDS CCDS24693
HPRD
IMGT
MGI ID MGI:96552
MGI Symbol Il3
EMBL AK153634 BC125552 BC125554 CH466575 K01668 K01850 K03233 M14394 M20128 X02732
GenPept AAA39291 AAA39293 AAA39308 AAA39507 AAI25553 AAI25555 BAE32129 CAA26514 EDL33539
RNA Seq Atlas 16187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca