Homo sapiens Gene: ASH2L
Summary
InnateDB Gene IDBG-17300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASH2L
Gene Name ash2 (absent, small, or homeotic)-like (Drosophila)
Synonyms ASH2; ASH2L1; ASH2L2; Bre2;
Species Homo sapiens
Ensembl Gene ENSG00000129691
Encoded Proteins
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
ash2 (absent, small, or homeotic)-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:38105242-38144076
Strand Forward strand
Band p11.23
Transcripts
ENST00000343823 ENSP00000340896
ENST00000428278 ENSP00000395310
ENST00000517719 ENSP00000428877
ENST00000517496 ENSP00000430889
ENST00000521652 ENSP00000430259
ENST00000524263
ENST00000522675
ENST00000518186
ENST00000524247 ENSP00000429387
ENST00000521808 ENSP00000427839
ENST00000520079
ENST00000545394 ENSP00000443606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 117 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 117 [view]
Protein-Protein 111 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006974 cellular response to DNA damage stimulus
GO:0008284 positive regulation of cell proliferation
GO:0030097 hemopoiesis
GO:0043627 response to estrogen
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
deactivation of the beta-catenin transactivating complex pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.521530 Hs.608756
RefSeq NM_001105214 NM_001261832 NM_001282272 NM_004674 XM_005273682 XM_005273683 XM_006716412 XM_006716413
HUGO
OMIM
CCDS CCDS47840 CCDS59100 CCDS6101 CCDS64872
HPRD 05309
IMGT
EMBL
GenPept
RNA Seq Atlas