InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Efna2

Summary

InnateDB Gene

IDBG-173153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efna2

Gene Name

ephrin A2

Synonyms

CEK7L; Elf1; Epl6; Eplg6; Lerk6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003070

Encoded Proteins

IDBP-173155

ephrin A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099617:
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80179482-80190010

Strand

Forward strand

Band

Transcripts

ENSMUST00000003154

ENSMUSP00000003154

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0007411	axon guidance
GO:0021772	olfactory bulb development
GO:0030316	osteoclast differentiation
GO:0046849	bone remodeling
GO:0048013	ephrin receptor signaling pathway