Version 5.4
Homo sapiens Gene: EFNA2
Summary
InnateDB Gene IDBG-14206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFNA2
Gene Name ephrin-A2
Synonyms ELF-1; EPLG6; HEK7-L; LERK-6; LERK6
Species Homo sapiens
Ensembl Gene ENSG00000099617
Encoded Proteins
IDBP-14208
ephrin-A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1286154-1300237
Strand Forward strand
Band p13.3
Transcripts
ENST00000215368 ENSP00000215368
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0021772 olfactory bulb development
GO:0030316 osteoclast differentiation
GO:0046849 bone remodeling
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0031594 neuromuscular junction
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003070
View Gene Order
ENSBTAG00000038221
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
epha_fwdpathway
EPHA forward signaling
Cross-References
SwissProt O43921
TrEMBL Q9HCB5
UniProt Splice Variant
Entrez Gene 1943
UniGene Hs.741510
RefSeq NM_001405
HUGO HGNC:3222
OMIM 602756
CCDS CCDS12061
HPRD 04132
IMGT
EMBL AC004258 AC005330 AJ007292 U92893 U92894 U92896
GenPept AAC04896 AAC39577 AAG16277 CAA07435
RNA Seq Atlas 1943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca