Version 5.4
Mus musculus Gene: Apc2
Summary
InnateDB Gene IDBG-173537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apc2
Gene Name adenomatosis polyposis coli 2
Synonyms AI852447; APCL; R75424
Species Mus musculus
Ensembl Gene ENSMUSG00000020135
Encoded Proteins
IDBP-173539
adenomatosis polyposis coli 2
IDBP-271045
adenomatosis polyposis coli 2
IDBP-542913
adenomatosis polyposis coli 2
IDBP-542914
adenomatosis polyposis coli 2
IDBP-542915
adenomatosis polyposis coli 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115266:
Gene Information
Type Protein coding
Genomic Location Chromosome 10:80295977-80318263
Strand Forward strand
Band C1
Transcripts
ENSMUST00000020349 ENSMUSP00000020349
ENSMUST00000105359 ENSMUSP00000100996
ENSMUST00000154212 ENSMUSP00000118171
ENSMUST00000140658
ENSMUST00000140828 ENSMUSP00000121324
ENSMUST00000138909 ENSMUSP00000116795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
Biological Process
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0035414 negative regulation of catenin import into nucleus
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005881 cytoplasmic microtubule
GO:0005884 actin filament
GO:0015630 microtubule cytoskeleton
GO:0016342 catenin complex
GO:0031258 lamellipodium membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115266
View Gene Order
ENSBTAG00000015433
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05213
Endometrial cancer pathway
mmu05217
Basal cell carcinoma pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05213
Endometrial cancer pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.57247
RefSeq NM_011789 XM_006513643 XM_006513644 XM_006513645 XM_006513646
OMIM
CCDS CCDS24016
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca