Version 5.4
Mus musculus Gene: Prpf3
Summary
InnateDB Gene IDBG-173824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prpf3
Gene Name PRP3 pre-mRNA processing factor 3 homolog (yeast)
Synonyms 3632413F13Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000015748
Encoded Proteins
IDBP-173826
PRP3 pre-mRNA processing factor 3 homolog (yeast)
IDBP-534606
PRP3 pre-mRNA processing factor 3 homolog (yeast)
IDBP-539423
PRP3 pre-mRNA processing factor 3 homolog (yeast)
IDBP-535340
PRP3 pre-mRNA processing factor 3 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117360:
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:95830124-95855885
Strand Reverse strand
Band F2.1
Transcripts
ENSMUST00000015892 ENSMUSP00000015892
ENSMUST00000159901 ENSMUSP00000124444
ENSMUST00000160155
ENSMUST00000161476 ENSMUSP00000124950
ENSMUST00000163059
ENSMUST00000161482
ENSMUST00000161420
ENSMUST00000160109 ENSMUSP00000124302
ENSMUST00000161073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117360
View Gene Order
ENSBTAG00000013946
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q922U1
TrEMBL
UniProt Splice Variant
Entrez Gene 70767
UniGene Mm.279872
RefSeq XM_006502079 XM_006502080 XM_006502082 NM_027541
OMIM
CCDS CCDS17621
HPRD
IMGT
MGI ID MGI:1918017
MGI Symbol Prpf3
EMBL AK014398 AK088194 AK167435 BC006782
GenPept AAH06782 BAB29324 BAC40202 BAE39521
RNA Seq Atlas 70767

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca