Version 5.4
Mus musculus Protein: Prpf3
Summary
InnateDB Protein IDBP-539423.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prpf3
Protein Name PRP3 pre-mRNA processing factor 3 homolog (yeast)
Synonyms 3632413F13Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000124950
InnateDB Gene IDBG-173824 (Prpf3)
Protein Structure
UniProt Annotation
Function Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus speckle {ECO:0000255PROSITE- ProRule:PRU00627}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
Cellular Component
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
Protein Structure and Domains
PDB ID MGI:1918017
InterPro IPR002483 PWI domain
IPR010541 Domain of unknown function DUF1115
IPR013881 Pre-mRNA-splicing factor 3
PFAM PF01480
PF06544
PF08572
PRINTS
PIRSF
SMART SM00311
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922U1
PhosphoSite PhosphoSite-Q922U1
TrEMBL
UniProt Splice Variant
Entrez Gene 70767
UniGene Mm.279872
RefSeq NP_081817
MGI ID
MGI Symbol Prpf3
OMIM
CCDS CCDS17621
HPRD
IMGT
EMBL AK014398 AK088194 AK167435 BC006782
GenPept AAH06782 BAB29324 BAC40202 BAE39521

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca