Version 5.4
Homo sapiens Gene: A2ML1
Summary
InnateDB Gene IDBG-17392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2ML1
Gene Name alpha-2-macroglobulin-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166535
Encoded Proteins
IDBP-17396
alpha-2-macroglobulin-like 1
IDBP-591353
alpha-2-macroglobulin-like 1
IDBP-593287
alpha-2-macroglobulin-like 1
IDBP-584118
alpha-2-macroglobulin-like 1
IDBP-585261
alpha-2-macroglobulin-like 1
IDBP-601631
alpha-2-macroglobulin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8822472-8887001
Strand Forward strand
Band p13.31
Transcripts
ENST00000299698 ENSP00000299698
ENST00000537546
ENST00000541459 ENSP00000443174
ENST00000536789 ENSP00000440662
ENST00000539547 ENSP00000438292
ENST00000545692 ENSP00000440057
ENST00000540049
ENST00000545850
ENST00000537475 ENSP00000445674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0052548 regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL F5GXP1
UniProt Splice Variant
Entrez Gene 144568
UniGene Hs.334306 Hs.620532
RefSeq NM_001282424 NM_144670
HUGO HGNC:23336
OMIM 610627
CCDS CCDS73439 CCDS8596
HPRD 08684
IMGT
EMBL AC006513 AC006581
GenPept
RNA Seq Atlas 144568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca