Homo sapiens Gene: A2ML1
Summary
InnateDB Gene IDBG-17392.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2ML1
Gene Name alpha-2-macroglobulin-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166535
Encoded Proteins
alpha-2-macroglobulin-like 1
alpha-2-macroglobulin-like 1
alpha-2-macroglobulin-like 1
alpha-2-macroglobulin-like 1
alpha-2-macroglobulin-like 1
alpha-2-macroglobulin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8822472-8887001
Strand Forward strand
Band p13.31
Transcripts
ENST00000299698 ENSP00000299698
ENST00000537546
ENST00000541459 ENSP00000443174
ENST00000536789 ENSP00000440662
ENST00000539547 ENSP00000438292
ENST00000545692 ENSP00000440057
ENST00000540049
ENST00000545850
ENST00000537475 ENSP00000445674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0052548 regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.334306 Hs.620532
RefSeq NM_001282424 NM_144670
HUGO
OMIM
CCDS CCDS73439 CCDS8596
HPRD 08684
IMGT
EMBL
GenPept
RNA Seq Atlas