Version 5.4
Homo sapiens Protein: A2ML1
Summary
InnateDB Protein IDBP-584118.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol A2ML1
Protein Name alpha-2-macroglobulin-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000438292
InnateDB Gene IDBG-17392 (A2ML1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001599 Alpha-2-macroglobulin
IPR007990 Seminal vesicle autoantigen
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
IPR009048 Alpha-macroglobulin, receptor-binding
IPR011625 Alpha-2-macroglobulin, N-terminal 2
IPR011626 Alpha-macroglobulin complement component
IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
PFAM PF00207
PF05326
PF07677
PF07703
PF07678
PF10569
PRINTS
PIRSF PIRSF002572
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F5H2Z2
UniProt Splice Variant
Entrez Gene 144568
UniGene Hs.620532
RefSeq NP_001269353
HUGO HGNC:23336
OMIM 610627
CCDS CCDS73439
HPRD 08684
IMGT
EMBL AC006513 AC006581
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca