InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: F2rl1

Summary

InnateDB Gene

IDBG-173973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F2rl1

Gene Name

coagulation factor II (thrombin) receptor-like 1

Synonyms

Gpcr11; PAR-2; Par2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021678

Encoded Proteins

IDBP-173975

coagulation factor II (thrombin) receptor-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18622013

[Homo sapiens] F2RL1 and TLR4 interact in a synthetic agonist peptide-dependent manner and may support a novel paradigm of receptor cooperativity in inflammatory responses.

PMID 19675284

[Homo sapiens] F2RL1 is involved in inflammation and is specifically activated by mast cell-derived tryptase.

PMID 11907122

[Homo sapiens] Activation of F2RL1 stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells, thus having an important role in modulating inflammation in the lung.

PMID 19865078

[Homo sapiens] F2RL1 cooperates with TLR2, TLR3, or TLR4 for activation of nuclear factor-kappaB-dependent signalling in mucosal epithelial cell lines.

PMID 19865078

[Homo sapiens] Activation of F2RL1 negatively regulates TLR3-dependent antiviral pathway, blunting the expression of TLR3/IRF3 driven genes, as well as activation of IRF3 and STAT1.

PMID 21029417

[Homo sapiens] F2RL1 (PAR2) activates MAPK14 (p38) to trigger production of innate immunity markers in oral kertainocytes.

PMID 24129891

[Homo sapiens] IL32 interacts with PR3 and F2RL1, triggering the PAR2-TRIF signalling axis, and IL32 may have a potential role in the transition from innate to adaptive immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164251:
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83%% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:95511732-95525240

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022185

ENSMUSP00000022185

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015057	thrombin receptor activity
GO:0031681	G-protein beta-subunit binding
GO:0032795	heterotrimeric G-protein binding

Biological Process

GO:0002286	T cell activation involved in immune response
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0002741	positive regulation of cytokine secretion involved in immune response
GO:0003104	positive regulation of glomerular filtration
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030193	regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0030836	positive regulation of actin filament depolymerization
GO:0031274	positive regulation of pseudopodium assembly
GO:0032930	positive regulation of superoxide anion generation
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0035025	positive regulation of Rho protein signal transduction
GO:0035926	chemokine (C-C motif) ligand 2 secretion
GO:0042119	neutrophil activation
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043311	positive regulation of eosinophil degranulation
GO:0045087	innate immune response
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046328	regulation of JNK cascade
GO:0046329	negative regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade
GO:0050702	interleukin-1 beta secretion
GO:0050900	leukocyte migration
GO:0050921	positive regulation of chemotaxis
GO:0050927	positive regulation of positive chemotaxis
GO:0051607	defense response to virus
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070493	thrombin receptor signaling pathway
GO:0070661	leukocyte proliferation
GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium
GO:0072608	interleukin-10 secretion
GO:0072643	interferon-gamma secretion
GO:0090195	chemokine secretion
GO:0090198	negative regulation of chemokine secretion
GO:0097029	mature dendritic cell differentiation
GO:1900135	positive regulation of renin secretion into blood stream
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion