Homo sapiens Gene: F2RL1
Summary
InnateDB Gene IDBG-29713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F2RL1
Gene Name coagulation factor II (thrombin) receptor-like 1
Synonyms GPR11; PAR2;
Species Homo sapiens
Ensembl Gene ENSG00000164251
Encoded Proteins
coagulation factor II (thrombin) receptor-like 1
coagulation factor II (thrombin) receptor-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
F2RL1 and TLR4 interact in a synthetic agonist peptide-dependent manner and may support a novel paradigm of receptor cooperativity in inflammatory responses.
F2RL1 is involved in inflammation and is specifically activated by mast cell-derived tryptase.
Activation of F2RL1 stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells, thus having an important role in modulating inflammation in the lung.
F2RL1 cooperates with TLR2, TLR3, or TLR4 for activation of nuclear factor-kappaB-dependent signalling in mucosal epithelial cell lines.
Activation of F2RL1 negatively regulates TLR3-dependent antiviral pathway, blunting the expression of TLR3/IRF3 driven genes, as well as activation of IRF3 and STAT1.
F2RL1 (PAR2) activates MAPK14 (p38) to trigger production of innate immunity markers in oral kertainocytes.
IL32 interacts with PR3 and F2RL1, triggering the PAR2-TRIF signalling axis, and IL32 may have a potential role in the transition from innate to adaptive immunity.
Entrez Gene
Summary Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83%% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76818933-76835315
Strand Forward strand
Band q13.3
Transcripts
ENST00000296677 ENSP00000296677
ENST00000514165 ENSP00000425622
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004872 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0015057 thrombin receptor activity
GO:0031681 G-protein beta-subunit binding
Biological Process
GO:0002286 T cell activation involved in immune response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0003104 positive regulation of glomerular filtration
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030193 regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030836 positive regulation of actin filament depolymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0032930 positive regulation of superoxide anion generation
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034140 negative regulation of toll-like receptor 3 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035926 chemokine (C-C motif) ligand 2 secretion
GO:0042119 neutrophil activation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043311 positive regulation of eosinophil degranulation
GO:0045087 innate immune response (InnateDB)
GO:0045909 positive regulation of vasodilation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0050702 interleukin-1 beta secretion
GO:0050900 leukocyte migration
GO:0050921 positive regulation of chemotaxis
GO:0050927 positive regulation of positive chemotaxis
GO:0051607 defense response to virus
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0061028 establishment of endothelial barrier
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070493 thrombin receptor signaling pathway
GO:0070661 leukocyte proliferation
GO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium
GO:0072608 interleukin-10 secretion
GO:0072643 interferon-gamma secretion
GO:0090195 chemokine secretion
GO:0090198 negative regulation of chemokine secretion
GO:0097029 mature dendritic cell differentiation
GO:1900135 positive regulation of renin secretion into blood stream
GO:2000484 positive regulation of interleukin-8 secretion
GO:2000778 positive regulation of interleukin-6 secretion
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0031143 pseudopodium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
African trypanosomiasis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.154299 Hs.743692
RefSeq NM_005242
HUGO
OMIM
CCDS CCDS4033
HPRD 02960
IMGT
EMBL
GenPept
RNA Seq Atlas