Version 5.4
Mus musculus Gene: Mapk8ip2
Summary
InnateDB Gene IDBG-174299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapk8ip2
Gene Name mitogen-activated protein kinase 8 interacting protein 2
Synonyms 3230402N03Rik; AI847694; AW049958; IB2; Jip2; R75148
Species Mus musculus
Ensembl Gene ENSMUSG00000022619
Encoded Proteins
IDBP-174301
mitogen-activated protein kinase 8 interacting protein 2
IDBP-542648
mitogen-activated protein kinase 8 interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008735:
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:89453913-89464468
Strand Forward strand
Band E3
Transcripts
ENSMUST00000023291 ENSMUSP00000023291
ENSMUST00000137755 ENSMUSP00000119189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0030295 protein kinase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0000165 MAPK cascade
GO:0001662 behavioral fear response
GO:0007254 JNK cascade
GO:0007617 mating behavior
GO:0010469 regulation of receptor activity
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035176 social behavior
GO:0045860 positive regulation of protein kinase activity
GO:0046328 regulation of JNK cascade
GO:0046958 nonassociative learning
GO:0048813 dendrite morphogenesis
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000008735
View Gene Order
ENSBTAG00000030179
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 60597
UniGene Mm.173337 Mm.482169 Mm.487064
RefSeq NM_021921
OMIM
CCDS CCDS27752
HPRD
IMGT
MGI ID MGI:1926555
MGI Symbol Mapk8ip2
EMBL
GenPept
RNA Seq Atlas 60597

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca