Version 5.4
Homo sapiens Gene: MAPK8IP2
Summary
InnateDB Gene IDBG-14068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK8IP2
Gene Name mitogen-activated protein kinase 8 interacting protein 2
Synonyms IB-2; IB2; JIP2; PRKM8IPL
Species Homo sapiens
Ensembl Gene ENSG00000008735
Encoded Proteins
IDBP-14070
mitogen-activated protein kinase 8 interacting protein 2
IDBP-14074
mitogen-activated protein kinase 8 interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50600685-50613981
Strand Forward strand
Band q13.33
Transcripts
ENST00000329492 ENSP00000330572
ENST00000008876 ENSP00000008876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 93 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005078 MAP-kinase scaffold activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0030295 protein kinase activator activity
GO:0032403 protein complex binding
Biological Process
GO:0000165 MAPK cascade
GO:0001662 behavioral fear response
GO:0007172 signal complex assembly
GO:0007254 JNK cascade
GO:0007617 mating behavior
GO:0009967 positive regulation of signal transduction
GO:0010469 regulation of receptor activity
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035176 social behavior
GO:0045860 positive regulation of protein kinase activity
GO:0046328 regulation of JNK cascade
GO:0046958 nonassociative learning
GO:0048813 dendrite morphogenesis
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022619
View Gene Order
ENSBTAG00000030179
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q13387
TrEMBL A8MTJ1 J3KNN6
UniProt Splice Variant
Entrez Gene 23542
UniGene Hs.558180 Hs.656617
RefSeq NM_012324 NM_016431
HUGO HGNC:6883
OMIM 607755
CCDS CCDS74886
HPRD
IMGT
EMBL AF136382 AF218778 AL021708 BC009940 U62317 U79261
GenPept AAB03340 AAB50207 AAF00980 AAF32323 AAH09940 CAA16714
RNA Seq Atlas 23542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca