InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RNF6

Summary

InnateDB Gene

IDBG-17430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF6

Gene Name

ring finger protein (C3H2C3 type) 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000127870

Encoded Proteins

IDBP-17434

ring finger protein (C3H2C3 type) 6

IDBP-17436

ring finger protein (C3H2C3 type) 6

IDBP-17438

ring finger protein (C3H2C3 type) 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:26132115-26222493

Strand

Reverse strand

Band

q12.13

Transcripts

ENST00000381588	ENSP00000371000
ENST00000346166	ENSP00000342121
ENST00000381570	ENSP00000370982
ENST00000468480
ENST00000498039
ENST00000476347
ENST00000474280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030517	negative regulation of axon extension
GO:0044314	protein K27-linked ubiquitination
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070936	protein K48-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016605	PML body
GO:0030424	axon
GO:0031965	nuclear membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029634

View Gene Order

ENSBTAG00000005318

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.136885 Hs.609300 Hs.717954

RefSeq

NM_005977 NM_183043 NM_183044 XM_005266485 XM_005266486

HUGO

OMIM

CCDS

CCDS9316

HPRD

05027

IMGT

EMBL

GenPept

RNA Seq Atlas