Version 5.4
Mus musculus Gene: Rnf6
Summary
InnateDB Gene IDBG-208802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf6
Gene Name ring finger protein (C3H2C3 type) 6
Synonyms 1200013I08Rik; 5730419H05Rik; AA537053
Species Mus musculus
Ensembl Gene ENSMUSG00000029634
Encoded Proteins
IDBP-208804
ring finger protein (C3H2C3 type) 6
IDBP-537974
ring finger protein (C3H2C3 type) 6
IDBP-539512
ring finger protein (C3H2C3 type) 6
IDBP-531824
ring finger protein (C3H2C3 type) 6
IDBP-538497
ring finger protein (C3H2C3 type) 6
IDBP-534859
ring finger protein (C3H2C3 type) 6
IDBP-621715
ring finger protein (C3H2C3 type) 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127870:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:146209192-146221555
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000067837 ENSMUSP00000067559
ENSMUST00000161859 ENSMUSP00000124293
ENSMUST00000162219 ENSMUSP00000123708
ENSMUST00000161574 ENSMUSP00000123730
ENSMUST00000161331 ENSMUSP00000125611
ENSMUST00000159074 ENSMUSP00000123926
ENSMUST00000161725
ENSMUST00000169407 ENSMUSP00000128774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0030517 negative regulation of axon extension
GO:0044314 protein K27-linked ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060765 regulation of androgen receptor signaling pathway
GO:0070936 protein K48-linked ubiquitination
GO:0085020 protein K6-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016605 PML body
GO:0030424 axon
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127870
View Gene Order
ENSBTAG00000005318
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.26696 Mm.474638 Mm.489862
RefSeq NM_001256085 NM_001256086 NM_001256087 NM_028774
OMIM
CCDS CCDS19868
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca