Version 5.4
Homo sapiens Gene: LIFR
Summary
InnateDB Gene IDBG-17489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIFR
Gene Name leukemia inhibitory factor receptor alpha
Synonyms CD118; LIF-R; SJS2; STWS; SWS
Species Homo sapiens
Ensembl Gene ENSG00000113594
Encoded Proteins
IDBP-17491
leukemia inhibitory factor receptor alpha
IDBP-365512
leukemia inhibitory factor receptor alpha
IDBP-478111
leukemia inhibitory factor receptor alpha
IDBP-481150
leukemia inhibitory factor receptor alpha
IDBP-474104
leukemia inhibitory factor receptor alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:38474963-38608354
Strand Reverse strand
Band p13.1
Transcripts
ENST00000263409 ENSP00000263409
ENST00000453190 ENSP00000398368
ENST00000508477
ENST00000506003 ENSP00000426919
ENST00000503088
ENST00000506990 ENSP00000426685
ENST00000512723
ENST00000511561 ENSP00000427310
ENST00000507786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0004923 leukemia inhibitory factor receptor activity
GO:0004924 oncostatin-M receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005515 protein binding
GO:0019838 growth factor binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0034097 response to cytokine
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054263
View Gene Order
ENSBTAG00000010423
Not yet available
Pathways
NETPATH
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
LIF signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133421 Hs.594542 Hs.616721
RefSeq NM_001127671 NM_002310
HUGO
OMIM
CCDS CCDS3927
HPRD 01048
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca