InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pias1

Summary

InnateDB Gene

IDBG-175037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pias1

Gene Name

protein inhibitor of activated STAT 1

Synonyms

2900068C24Rik; Ddxbp1; GBP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032405

Encoded Proteins

IDBP-175041

protein inhibitor of activated STAT 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12855578

[Homo sapiens] PIAS1 and other PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation is a modulatory mechanism for several transcription factors.

PMID 19136629

[Homo sapiens] PIAS1 is a protein inhibitor of activated STAT1 and arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in interferon (IFN)-dependent transcription as well as for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033800:
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:62880077-62980879

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098651

ENSMUSP00000096248

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007259	JAK-STAT cascade
GO:0007283	spermatogenesis
GO:0016925	protein sumoylation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033235	positive regulation of protein sumoylation
GO:0042127	regulation of cell proliferation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051152	positive regulation of smooth muscle cell differentiation
GO:0065004	protein-DNA complex assembly