Bos taurus Gene: PIAS1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-645488.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | PIAS1 | ||||||||||||||
Gene Name | E3 SUMO-protein ligase PIAS1 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000005564 | ||||||||||||||
Encoded Proteins |
E3 SUMO-protein ligase PIAS1
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] PIAS1 and other PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation is a modulatory mechanism for several transcription factors.
[Homo sapiens] PIAS1 is a protein inhibitor of activated STAT1 and arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in interferon (IFN)-dependent transcription as well as for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033800:
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 10:14878655-15004134 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
AndrogenReceptor pathway
TGF_beta_Receptor pathway
IL11 pathway
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REACTOME |
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
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KEGG |
Ubiquitin mediated proteolysis pathway
Jak-STAT signaling pathway pathway
Hepatitis C pathway
Ubiquitin mediated proteolysis pathway
Jak-STAT signaling pathway pathway
Hepatitis C pathway
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INOH | |||||||||||||||
PID NCI |
Coregulation of Androgen receptor activity
Signaling events mediated by TCPTP
Sumoylation by RanBP2 regulates transcriptional repression
Hedgehog signaling events mediated by Gli proteins
IL6-mediated signaling events
IFN-gamma pathway
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | Q24JZ9 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 509231 | ||||||||||||||
UniGene | Bt.6797 | ||||||||||||||
RefSeq | NM_001075396 XM_005211290 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC114146 DAAA02027922 DAAA02027923 DAAA02027924 | ||||||||||||||
GenPept | AAI14147 | ||||||||||||||
RNA Seq Atlas | 509231 | ||||||||||||||