Homo sapiens Gene: KLRG1
Summary
InnateDB Gene IDBG-17564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLRG1
Gene Name killer cell lectin-like receptor subfamily G, member 1
Synonyms 2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE;
Species Homo sapiens
Ensembl Gene ENSG00000139187
Encoded Proteins
killer cell lectin-like receptor subfamily G, member 1
killer cell lectin-like receptor subfamily G, member 1
killer cell lectin-like receptor subfamily G, member 1
killer cell lectin-like receptor subfamily G, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8950044-9010760
Strand Forward strand
Band p13.31
Transcripts
ENST00000266551 ENSP00000266551
ENST00000356986 ENSP00000349477
ENST00000539240 ENSP00000445627
ENST00000544226
ENST00000538029
ENST00000541957
ENST00000543895 ENSP00000443658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558446
RefSeq NM_005810 XM_006719026
HUGO
OMIM
CCDS CCDS8599
HPRD 16076
IMGT
EMBL
GenPept
RNA Seq Atlas