Version 5.4
Homo sapiens Gene: KLRG1
Summary
InnateDB Gene IDBG-17564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLRG1
Gene Name killer cell lectin-like receptor subfamily G, member 1
Synonyms 2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MAFA-LIKE
Species Homo sapiens
Ensembl Gene ENSG00000139187
Encoded Proteins
IDBP-17566
killer cell lectin-like receptor subfamily G, member 1
IDBP-17568
killer cell lectin-like receptor subfamily G, member 1
IDBP-592216
killer cell lectin-like receptor subfamily G, member 1
IDBP-599914
killer cell lectin-like receptor subfamily G, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8950044-9010760
Strand Forward strand
Band p13.31
Transcripts
ENST00000266551 ENSP00000266551
ENST00000356986 ENSP00000349477
ENST00000539240 ENSP00000445627
ENST00000544226
ENST00000538029
ENST00000541957
ENST00000543895 ENSP00000443658
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0030246 carbohydrate binding
Biological Process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007166 cell surface receptor signaling pathway
GO:0045087 innate immune response
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030114
View Gene Order
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558446
RefSeq NM_005810 XM_006719026
HUGO
OMIM
CCDS CCDS8599
HPRD 16076
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca