InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sf3a2

Summary

InnateDB Gene

IDBG-176078.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sf3a2

Gene Name

splicing factor 3a, subunit 2

Synonyms

66kDa; AW047242; PRP11; Sap62; SFA66

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020211

Encoded Proteins

IDBP-534044

splicing factor 3a, subunit 2

IDBP-541582

splicing factor 3a, subunit 2

IDBP-538924

splicing factor 3a, subunit 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104897:
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80798198-80804924

Strand

Forward strand

Band

Transcripts

ENSMUST00000148665	ENSMUSP00000117160
ENSMUST00000151928	ENSMUSP00000114164
ENSMUST00000147440	ENSMUSP00000116478
ENSMUST00000139461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 125 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	125 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000104897

View Gene Order

ENSBTAG00000025452

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03040

Spliceosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

REACT_205948

mRNA Splicing - Major Pathway pathway

REACT_206725

mRNA Splicing pathway

REACT_226022

Gene Expression pathway

REACT_226302

Processing of Capped Intron-Containing Pre-mRNA pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.358633

RefSeq

NM_013651 XM_006513394 XM_006513395 XM_006513396 XM_006513397

OMIM

CCDS

CCDS35986

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas