Version 5.4
Mus musculus Gene: Nefm
Summary
InnateDB Gene IDBG-176543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nefm
Gene Name neurofilament, medium polypeptide
Synonyms Nef3; NF-M; NF160; NF165; Nfm
Species Mus musculus
Ensembl Gene ENSMUSG00000022054
Encoded Proteins
IDBP-176545
neurofilament, medium polypeptide
IDBP-258876
neurofilament, medium polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104722:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:68082590-68124846
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000022638 ENSMUSP00000022638
ENSMUST00000111089 ENSMUSP00000106718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008088 axon cargo transport
GO:0031133 regulation of axon diameter
GO:0045104 intermediate filament cytoskeleton organization
GO:0045110 intermediate filament bundle assembly
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0030424 axon
GO:0031594 neuromuscular junction
GO:0043005 neuron projection
GO:0097418 neurofibrillary tangle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104722
View Gene Order
ENSBTAG00000039530
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.390700 Mm.468698
RefSeq NM_008691
OMIM
CCDS CCDS27233
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca