Bos taurus Gene: NEFM
Summary
InnateDB Gene IDBG-635359.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEFM
Gene Name neurofilament, medium polypeptide
Synonyms NEF3; NF-M;
Species Bos taurus
Ensembl Gene ENSBTAG00000039530
Encoded Proteins
neurofilament, medium polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104722:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:73147853-73152844
Strand Forward strand
Band
Transcripts
ENSBTAT00000036581 ENSBTAP00000036438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0008088 axon cargo transport
GO:0031133 regulation of axon diameter
GO:0045104 intermediate filament cytoskeleton organization
GO:0045110 intermediate filament bundle assembly
GO:0060052 neurofilament cytoskeleton organization
Cellular Component
GO:0005882 intermediate filament
GO:0005883 neurofilament
GO:0030424 axon
GO:0031594 neuromuscular junction
GO:0043005 neuron projection
GO:0097418 neurofibrillary tangle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Amyotrophic lateral sclerosis (ALS) pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MDZ2 Q6TGK6
UniProt Splice Variant
Entrez Gene 281347
UniGene Bt.51690
RefSeq NM_001244145 XM_003582558
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY421963 DAAA02023646
GenPept AAQ96173
RNA Seq Atlas 100852255 281347
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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