Version 5.4
Homo sapiens Gene: TJP3
Summary
InnateDB Gene IDBG-17677.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TJP3
Gene Name tight junction protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105289
Encoded Proteins
IDBP-603763
tight junction protein 3 (zona occludens 3)
IDBP-601684
tight junction protein 3 (zona occludens 3)
IDBP-764878
IDBP-763632
IDBP-761898
IDBP-764031
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3708109-3750813
Strand Forward strand
Band p13.3
Transcripts
ENST00000541714 ENSP00000439278
ENST00000539908 ENSP00000439991
ENST00000589378 ENSP00000465419
ENST00000587912
ENST00000586032 ENSP00000465065
ENST00000590545 ENSP00000468641
ENST00000591493
ENST00000587641
ENST00000587686 ENSP00000467864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005923 tight junction
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034917
View Gene Order
ENSBTAG00000018342
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7ESC0
UniProt Splice Variant
Entrez Gene 27134
UniGene Hs.25527
RefSeq NM_001267560 NM_001267561 XM_005259539 XM_006722724
HUGO HGNC:11829
OMIM 612689
CCDS CCDS32873 CCDS59332
HPRD 18194
IMGT
EMBL AC005954 AC006125
GenPept
RNA Seq Atlas 27134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca