Mus musculus Gene: Pde6d
Summary
InnateDB Gene IDBG-177111.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde6d
Gene Name phosphodiesterase 6D, cGMP-specific, rod, delta
Synonyms AI841218; PrBP/delta;
Species Mus musculus
Ensembl Gene ENSMUSG00000026239
Encoded Proteins
phosphodiesterase 6D, cGMP-specific, rod, delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156973:
This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86542994-86582629
Strand Reverse strand
Band C5
Transcripts
ENSMUST00000027444 ENSMUSP00000027444
ENSMUST00000148683
ENSMUST00000143674 ENSMUSP00000137956
ENSMUST00000150653
ENSMUST00000146220 ENSMUSP00000137820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0008152 metabolic process
GO:0033124 regulation of GTP catabolic process
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005829 cytosol
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Purine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.469223
RefSeq NM_008801
OMIM
CCDS CCDS15121
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas