Version 5.4
Homo sapiens Gene: ASB2
Summary
InnateDB Gene IDBG-17712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASB2
Gene Name ankyrin repeat and SOCS box containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100628
Encoded Proteins
IDBP-17714
ankyrin repeat and SOCS box containing 2
IDBP-588833
ankyrin repeat and SOCS box containing 2
IDBP-595380
ankyrin repeat and SOCS box containing 2
IDBP-602522
ankyrin repeat and SOCS box containing 2
IDBP-587469
ankyrin repeat and SOCS box containing 2
IDBP-598277
ankyrin repeat and SOCS box containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:93934153-93976791
Strand Reverse strand
Band q32.12
Transcripts
ENST00000315988 ENSP00000320675
ENST00000555019 ENSP00000451575
ENST00000553883
ENST00000555507 ENSP00000450940
ENST00000556337
ENST00000556062 ENSP00000451694
ENST00000555287 ENSP00000451654
ENST00000556793
ENST00000557613 ENSP00000451355
ENST00000555374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0035914 skeletal muscle cell differentiation
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045445 myoblast differentiation
Cellular Component
GO:0031466 Cul5-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021200
View Gene Order
ENSBTAG00000007109
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.510327 Hs.683678
RefSeq NM_001202429 NM_016150 XM_005267758
HUGO
OMIM
CCDS CCDS55940 CCDS9915
HPRD 05768
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca