InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASB2

Summary

InnateDB Protein

IDBP-588833.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASB2

Protein Name

ankyrin repeat and SOCS box containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000451575

InnateDB Gene

IDBG-17712 (ASB2)

Protein Structure

UniProt Annotation

Function

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15590664, ECO:0000269PubMed:16325183}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0035914	skeletal muscle cell differentiation
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045445	myoblast differentiation