Mus musculus Gene: Rcan1 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-177629.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Rcan1 | ||||||||||||||||||||||||
Gene Name | regulator of calcineurin 1 | ||||||||||||||||||||||||
Synonyms | Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; RCN1; | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000022951 | ||||||||||||||||||||||||
Encoded Proteins |
regulator of calcineurin 1
regulator of calcineurin 1
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||
Summary |
[Homo sapiens] RCAN1 (DSCR1) short isoform positively modulates IL-1R-mediated signalling pathways by regulating TOLLIP/IRAK1/TRAF6 complex formation.
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Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159200:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 16:92391953-92466146 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | C4 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||
KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID BIOCARTA | |||||||||||||||||||||||||
PID NCI |
Calcium signaling in the CD4+ TCR pathway
Notch-mediated HES/HEY network
Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Cross-References | |||||||||||||||||||||||||
SwissProt | Q9JHG6 | ||||||||||||||||||||||||
TrEMBL | Q542V6 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 54720 | ||||||||||||||||||||||||
UniGene | Mm.265744 Mm.455990 | ||||||||||||||||||||||||
RefSeq | NM_019466 NM_001081549 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS28337 CCDS37405 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | MGI:1890564 | ||||||||||||||||||||||||
MGI Symbol | Rcan1 | ||||||||||||||||||||||||
EMBL | AF237789 AF237790 AF260717 AF263239 AF263240 AF282255 AK010696 AK077283 BC013551 CH466602 | ||||||||||||||||||||||||
GenPept | AAF63485 AAF63486 AAF70343 AAF72701 AAF72702 AAF91461 AAH13551 BAB27128 BAC36729 EDL03783 | ||||||||||||||||||||||||
RNA Seq Atlas | 54720 | ||||||||||||||||||||||||