Version 5.4
Mus musculus Gene: Rcan1
Summary
InnateDB Gene IDBG-177629.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rcan1
Gene Name regulator of calcineurin 1
Synonyms Adapt78; CALP1L; CSP1; DSC1; Dscr1; MCIP1; RCN1;
Species Mus musculus
Ensembl Gene ENSMUSG00000022951
Encoded Proteins
IDBP-177631
regulator of calcineurin 1
IDBP-177633
regulator of calcineurin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19716405
[Homo sapiens] RCAN1 (DSCR1) short isoform positively modulates IL-1R-mediated signalling pathways by regulating TOLLIP/IRAK1/TRAF6 complex formation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159200:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:92391953-92466146
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000023672 ENSMUSP00000023672
ENSMUST00000060005 ENSMUSP00000060394
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002931 response to ischemia
GO:0006979 response to oxidative stress
GO:0007519 skeletal muscle tissue development
GO:0007614 short-term memory
GO:0009612 response to mechanical stimulus
GO:0019722 calcium-mediated signaling
GO:0031987 locomotion involved in locomotory behavior
GO:0033173 calcineurin-NFAT signaling cascade
GO:0043627 response to estrogen
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0048741 skeletal muscle fiber development
GO:0051151 negative regulation of smooth muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000159200
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000020035
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
hes_heypathway
Notch-mediated HES/HEY network
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt Q9JHG6
TrEMBL Q542V6
UniProt Splice Variant
Entrez Gene 54720
UniGene Mm.265744 Mm.455990
RefSeq NM_019466 NM_001081549
OMIM
CCDS CCDS28337 CCDS37405
HPRD
IMGT
MGI ID MGI:1890564
MGI Symbol Rcan1
EMBL AF237789 AF237790 AF260717 AF263239 AF263240 AF282255 AK010696 AK077283 BC013551 CH466602
GenPept AAF63485 AAF63486 AAF70343 AAF72701 AAF72702 AAF91461 AAH13551 BAB27128 BAC36729 EDL03783
RNA Seq Atlas 54720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca