Homo sapiens Gene: EPS8L2
Summary
InnateDB Gene IDBG-17790.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPS8L2
Gene Name EPS8-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177106
Encoded Proteins
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
EPS8-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:694438-727727
Strand Forward strand
Band p15.5
Transcripts
ENST00000318562 ENSP00000320828
ENST00000524763 ENSP00000435128
ENST00000527199 ENSP00000437085
ENST00000533256 ENSP00000435585
ENST00000534755 ENSP00000432923
ENST00000529346
ENST00000526909 ENSP00000433173
ENST00000529680
ENST00000530093
ENST00000533500 ENSP00000433223
ENST00000527807
ENST00000531348 ENSP00000432765
ENST00000526380
ENST00000530636 ENSP00000436035
ENST00000527021
ENST00000526198 ENSP00000436230
ENST00000530118
ENST00000524474
ENST00000531471
ENST00000526651
ENST00000532545
ENST00000528770 ENSP00000437145
ENST00000530452 ENSP00000433057
ENST00000533816
ENST00000531393
ENST00000527832
ENST00000534679
ENST00000534027
ENST00000534449
ENST00000524973
ENST00000614442 ENSP00000480201
ENST00000610855 ENSP00000480704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
Biological Process
GO:0007266 Rho protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.55016 Hs.626905
RefSeq NM_022772 XM_006718273 XM_006718274 XM_006718275 XM_006718276
HUGO
OMIM
CCDS CCDS31328
HPRD 10940
IMGT
EMBL
GenPept
RNA Seq Atlas