Version 5.4
Mus musculus Gene: Tlk1
Summary
InnateDB Gene IDBG-178108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tlk1
Gene Name tousled-like kinase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041997
Encoded Proteins
IDBP-178110
tousled-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198586:
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70712407-70825728
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000038584 ENSMUSP00000035961
ENSMUST00000135128
ENSMUST00000141707
ENSMUST00000152738
ENSMUST00000132542
ENSMUST00000133734
ENSMUST00000124629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001672 regulation of chromatin assembly or disassembly
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0016568 chromatin modification
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198586
View Gene Order
ENSBTAG00000006918
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.136511 Mm.408286
RefSeq NM_172664 XM_006499188 XM_006499192 XM_006499193 XM_006499194
OMIM
CCDS CCDS50599
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca