Version 5.4
Homo sapiens Gene: TLK1
Summary
InnateDB Gene IDBG-74812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLK1
Gene Name tousled-like kinase 1
Synonyms PKU-beta
Species Homo sapiens
Ensembl Gene ENSG00000198586
Encoded Proteins
IDBP-74814
tousled-like kinase 1
IDBP-74816
tousled-like kinase 1
IDBP-293652
tousled-like kinase 1
IDBP-387464
tousled-like kinase 1
IDBP-387467
tousled-like kinase 1
IDBP-387470
tousled-like kinase 1
IDBP-474980
tousled-like kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:170990823-171231314
Strand Reverse strand
Band q31.1
Transcripts
ENST00000360843 ENSP00000354089
ENST00000359766 ENSP00000352810
ENST00000409443 ENSP00000387313
ENST00000431350 ENSP00000411099
ENST00000434911 ENSP00000409222
ENST00000413010
ENST00000453628 ENSP00000393165
ENST00000521943 ENSP00000428113
ENST00000478683
ENST00000486857
ENST00000470340
ENST00000466220
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001672 regulation of chromatin assembly or disassembly
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0016310 phosphorylation
GO:0016568 chromatin modification
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041997
View Gene Order
ENSBTAG00000006918
Not yet available
Cross-References
SwissProt
TrEMBL F8W7X8
UniProt Splice Variant
Entrez Gene 9874
UniGene Hs.596942 Hs.731668
RefSeq NM_001136554 NM_001136555 NM_012290 XM_005246981 XM_006712883
HUGO HGNC:11841
OMIM 608438
CCDS CCDS2241 CCDS46447 CCDS46448
HPRD
IMGT
EMBL AC007739 AC009953 AC010092
GenPept
RNA Seq Atlas 9874

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca