|Mus musculus Gene: Rapgef5|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||Rap guanine nucleotide exchange factor (GEF) 5|
Rap guanine nucleotide exchange factor (GEF) 5
|Useful resources||Stemformatics EHFPI ImmGen|
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136237:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
|Genomic Location||Chromosome 12:117516479-117756978|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Not yet available
|UniProt Splice Variant|
|RNA Seq Atlas|