Mus musculus Gene: Hat1
Summary
InnateDB Gene IDBG-178800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hat1
Gene Name histone aminotransferase 1
Synonyms 2410071B14Rik; AA536933; Hat-1; KAT1
Species Mus musculus
Ensembl Gene ENSMUSG00000027018
Encoded Proteins
histone aminotransferase 1
histone aminotransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128708:
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71388958-71441622
Strand Forward strand
Band C2
Transcripts
ENSMUST00000028408 ENSMUSP00000028408
ENSMUST00000112122 ENSMUSP00000107750
ENSMUST00000144888
ENSMUST00000145147
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006348 chromatin silencing at telomere
GO:0007584 response to nutrient
GO:0016568 chromatin modification
GO:0016573 histone acetylation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Chromatin organization pathway
HATs acetylate histones pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BY71
TrEMBL
UniProt Splice Variant
Entrez Gene 107435
UniGene Mm.272472
RefSeq NM_026115
OMIM
CCDS CCDS16114
HPRD
IMGT
MGI ID MGI:96013
MGI Symbol Hat1
EMBL AK041700 AK169315 BC055460
GenPept AAH55460 BAC31038 BAE41070
RNA Seq Atlas 107435