InnateDB Protein
|
IDBP-178802.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Hat1
|
Protein Name
|
histone aminotransferase 1
|
Synonyms
|
2410071B14Rik; AA536933; Hat-1; KAT1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000028408
|
InnateDB Gene
|
IDBG-178800 (Hat1)
|
Protein Structure
|
|
Function |
Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus matrix {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
14 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004402
|
histone acetyltransferase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:96013
|
InterPro |
IPR016181
Acyl-CoA N-acyltransferase
IPR017380
Histone acetyltransferase type B, catalytic subunit
IPR019467
Histone acetyl transferase HAT1 N-terminal
|
PFAM |
PF10394
|
PRINTS |
|
PIRSF |
PIRSF038084
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8BY71
|
PhosphoSite |
PhosphoSite-Q8BY71
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
107435
|
UniGene |
Mm.272472
|
RefSeq |
NP_080391
|
MGI ID |
|
MGI Symbol |
Hat1
|
OMIM |
|
CCDS |
CCDS16114
|
HPRD |
|
IMGT |
|
EMBL |
AK041700
AK169315
BC055460
|
GenPept |
AAH55460
BAC31038
BAE41070
|
|
|