Version 5.4
Mus musculus Gene: Dgkd
Summary
InnateDB Gene IDBG-178894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dgkd
Gene Name diacylglycerol kinase, delta
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000070738
Encoded Proteins
IDBP-178898
diacylglycerol kinase, delta
IDBP-788844
diacylglycerol kinase, delta
IDBP-788847
diacylglycerol kinase, delta
IDBP-788848
diacylglycerol kinase, delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077044:
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:87853287-87945180
Strand Forward strand
Band D
Transcripts
ENSMUST00000027517 ENSMUSP00000027517
ENSMUST00000190243
ENSMUST00000191589
ENSMUST00000185260 ENSMUSP00000140070
ENSMUST00000190061 ENSMUSP00000139658
ENSMUST00000189726
ENSMUST00000189448 ENSMUSP00000139626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0010033 response to organic substance
GO:0016310 phosphorylation
GO:0035556 intracellular signal transduction
GO:0051260 protein homooligomerization
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077044
View Gene Order
ENSBTAG00000020616
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_2202
Effects of PIP2 hydrolysis pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PUQ8 Q6A0B7 Q80Y60
UniProt Splice Variant
Entrez Gene 227333
UniGene Mm.277217 Mm.411060
RefSeq NM_177646 XM_006529476
OMIM
CCDS CCDS48312
HPRD
IMGT
MGI ID MGI:2138334
MGI Symbol Dgkd
EMBL AC102630 AC162281 AK172901 BC048957
GenPept AAH48957 BAD32179
RNA Seq Atlas 227333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca