Mus musculus Gene: Itgb8
Summary
InnateDB Gene IDBG-178970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itgb8
Gene Name integrin beta 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025321
Encoded Proteins
integrin beta 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105855:
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:119158022-119238802
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000026360 ENSMUSP00000026360
ENSMUST00000151023
ENSMUST00000137804
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005102 receptor binding
Biological Process
GO:0001573 ganglioside metabolic process
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007275 multicellular organismal development
Cellular Component
GO:0008305 integrin complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Cell adhesion molecules (CAMs) pathway
Regulation of actin cytoskeleton pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
Integrin cell surface interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Cell adhesion molecules (CAMs) pathway
Regulation of actin cytoskeleton pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Integrin family cell surface interactions
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.217000 Mm.458027 Mm.461104 Mm.463671
RefSeq NM_177290 XM_006516016
OMIM
CCDS CCDS36580
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas