Mus musculus Gene: Dlx2
Summary
InnateDB Gene IDBG-178984.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlx2
Gene Name distal-less homeobox 2
Synonyms AW121999; Dlx-2; Tes-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000023391
Encoded Proteins
distal-less homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115844:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:71543408-71546754
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000024159 ENSMUSP00000024159
ENSMUST00000134249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0009954 proximal/distal pattern formation
GO:0021544 subpallium development
GO:0021766 hippocampus development
GO:0021772 olfactory bulb development
GO:0021879 forebrain neuron differentiation
GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021893 cerebral cortex GABAergic interneuron fate commitment
GO:0030154 cell differentiation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045746 negative regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048755 branching morphogenesis of a nerve
GO:0051216 cartilage development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3896 Mm.406674
RefSeq NM_010054
OMIM
CCDS CCDS16117
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas