InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dlx2

Summary

InnateDB Gene

IDBG-178984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlx2

Gene Name

distal-less homeobox 2

Synonyms

AW121999; Dlx-2; Tes-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023391

Encoded Proteins

IDBP-178986

distal-less homeobox 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115844:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:71543408-71546754

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024159	ENSMUSP00000024159
ENSMUST00000134249

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021772	olfactory bulb development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045746	negative regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048755	branching morphogenesis of a nerve
GO:0051216	cartilage development

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115844

View Gene Order

ENSBTAG00000005741

Not yet available

Cross-References

SwissProt

P40764

TrEMBL

Q52KJ2

UniProt Splice Variant

Entrez Gene

13392

UniGene

Mm.3896 Mm.406674

RefSeq

NM_010054

OMIM

CCDS

CCDS16117

HPRD

IMGT

MGI ID

MGI:94902

MGI Symbol

Dlx2

EMBL

AK144652 BC094317 CH466519 M80540 M83184 U51002

GenPept

AAA18487 AAA40412 AAB40901 AAH94317 BAE25991 EDL27093

RNA Seq Atlas

13392