InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLX2

Summary

InnateDB Gene

IDBG-75079.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLX2

Gene Name

distal-less homeobox 2

Synonyms

TES-1; TES1

Species

Homo sapiens

Ensembl Gene

ENSG00000115844

Encoded Proteins

IDBP-75081

distal-less homeobox 2

IDBP-592817

distal-less homeobox 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:172099439-172102900

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000234198	ENSP00000234198
ENST00000466293	ENSP00000446904

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0009954	proximal/distal pattern formation
GO:0021544	subpallium development
GO:0021766	hippocampus development
GO:0021772	olfactory bulb development
GO:0021879	forebrain neuron differentiation
GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021892	cerebral cortex GABAergic interneuron differentiation
GO:0021893	cerebral cortex GABAergic interneuron fate commitment
GO:0030154	cell differentiation
GO:0042475	odontogenesis of dentin-containing tooth
GO:0045746	negative regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048706	embryonic skeletal system development
GO:0048715	negative regulation of oligodendrocyte differentiation
GO:0048755	branching morphogenesis of a nerve
GO:0051216	cartilage development

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023391

View Gene Order

ENSBTAG00000005741

Not yet available

Cross-References

SwissProt

Q07687

TrEMBL

Q53QU7 X5D7D8

UniProt Splice Variant

Entrez Gene

1746

UniGene

RefSeq

NM_004405

HUGO

HGNC:2915

OMIM

126255

CCDS

CCDS2248

HPRD

IMGT

EMBL

AC104801 AK291367 AK297503 AK316129 BC032558 CH471058 KJ534825 L07919 U51003

GenPept

AAA19663 AAB40902 AAH32558 AAY14956 AHW56465 BAF84056 BAG59916 BAH14500 EAX11180

RNA Seq Atlas

1746