Version 5.4
Homo sapiens Gene: DIS3L
Summary
InnateDB Gene IDBG-17931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIS3L
Gene Name DIS3 mitotic control homolog (S. cerevisiae)-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166938
Encoded Proteins
IDBP-17933
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-17935
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-597998
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-584426
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-584551
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-601167
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-601107
DIS3 mitotic control homolog (S. cerevisiae)-like
IDBP-585013
DIS3 mitotic control homolog (S. cerevisiae)-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 15:66293217-66333898
Strand Forward strand
Band q22.31
Transcripts
ENST00000319194 ENSP00000321583
ENST00000319212 ENSP00000321711
ENST00000525134 ENSP00000435792
ENST00000524795 ENSP00000433504
ENST00000525109 ENSP00000432125
ENST00000532580 ENSP00000436583
ENST00000532293
ENST00000530615 ENSP00000436573
ENST00000530537 ENSP00000432407
ENST00000564909
ENST00000568874
ENST00000565281
ENST00000562314
ENST00000564945
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0016075 rRNA catabolic process
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0000177 cytoplasmic exosome (RNase complex)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032396
View Gene Order
ENSBTAG00000000371
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PKI7
UniProt Splice Variant
Entrez Gene 115752
UniGene Hs.446251
RefSeq NM_001143688 NM_133375 XM_005254144 XM_005254145 XM_005254147
HUGO HGNC:28698
OMIM 614183
CCDS CCDS10214 CCDS45286
HPRD 11355
IMGT
EMBL AC055855
GenPept
RNA Seq Atlas 115752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca