Homo sapiens Gene: DAB2
Summary
InnateDB Gene IDBG-17973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAB2
Gene Name disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Synonyms DOC-2; DOC2;
Species Homo sapiens
Ensembl Gene ENSG00000153071
Encoded Proteins
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:39371675-39462300
Strand Reverse strand
Band p13.1
Transcripts
ENST00000320816 ENSP00000313391
ENST00000339788 ENSP00000345508
ENST00000509337 ENSP00000426245
ENST00000502879
ENST00000512525
ENST00000505968
ENST00000507539 ENSP00000421526
ENST00000511792 ENSP00000427541
ENST00000503513 ENSP00000425088
ENST00000515700 ENSP00000421086
ENST00000513052
ENST00000515269
ENST00000511536
ENST00000509457
ENST00000502388
ENST00000507990
ENST00000545653 ENSP00000439919
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 80 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008022 protein C-terminus binding
GO:0030276 clathrin binding
GO:0035091 phosphatidylinositol binding
GO:0035612 AP-2 adaptor complex binding
GO:0035615 clathrin adaptor activity
GO:0038024 cargo receptor activity
GO:0046332 SMAD binding
Biological Process
GO:0000904 cell morphogenesis involved in differentiation
GO:0001701 in utero embryonic development
GO:0001921 positive regulation of receptor recycling
GO:0001934 positive regulation of protein phosphorylation
GO:0006907 pinocytosis
GO:0006915 apoptotic process
GO:0007257 activation of JUN kinase activity
GO:0007492 endoderm development
GO:0007588 excretion
GO:0008283 cell proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0030099 myeloid cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043066 negative regulation of apoptotic process
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048268 clathrin coat assembly
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0061024 membrane organization
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
GO:2000370 positive regulation of clathrin-mediated endocytosis
GO:2000643 positive regulation of early endosome to late endosome transport
GO:2001046 positive regulation of integrin-mediated signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016324 apical plasma membrane
GO:0030132 clathrin coat of coated pit
GO:0030665 clathrin-coated vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070022 transforming growth factor beta receptor homodimeric complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
Wnt pathway
REACTOME
Gap junction degradation pathway
Formation of annular gap junctions pathway
Gap junction trafficking pathway
Gap junction trafficking and regulation pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.594607 Hs.619757 Hs.696631
RefSeq NM_001244871 NM_001343
HUGO
OMIM
CCDS CCDS34149 CCDS58946
HPRD 03139
IMGT
EMBL
GenPept
RNA Seq Atlas