InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DAB2

Summary

InnateDB Gene

IDBG-17973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAB2

Gene Name

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

Synonyms

DOC-2; DOC2

Species

Homo sapiens

Ensembl Gene

ENSG00000153071

Encoded Proteins

IDBP-17975

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-17977

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-478205

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-480517

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-482148

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-478640

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-485394

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

IDBP-599344

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:39371675-39462300

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000320816	ENSP00000313391
ENST00000339788	ENSP00000345508
ENST00000509337	ENSP00000426245
ENST00000502879
ENST00000512525
ENST00000505968
ENST00000507539	ENSP00000421526
ENST00000511792	ENSP00000427541
ENST00000503513	ENSP00000425088
ENST00000515700	ENSP00000421086
ENST00000513052
ENST00000515269
ENST00000511536
ENST00000509457
ENST00000502388
ENST00000507990
ENST00000545653	ENSP00000439919

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008022	protein C-terminus binding
GO:0030276	clathrin binding
GO:0035091	phosphatidylinositol binding
GO:0035612	AP-2 adaptor complex binding
GO:0035615	clathrin adaptor activity
GO:0038024	cargo receptor activity
GO:0046332	SMAD binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0001701	in utero embryonic development
GO:0001921	positive regulation of receptor recycling
GO:0001934	positive regulation of protein phosphorylation
GO:0006907	pinocytosis
GO:0006915	apoptotic process
GO:0007257	activation of JUN kinase activity
GO:0007492	endoderm development
GO:0007588	excretion
GO:0008283	cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031	protein transport
GO:0016055	Wnt signaling pathway
GO:0030099	myeloid cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043066	negative regulation of apoptotic process
GO:0045785	positive regulation of cell adhesion
GO:0045807	positive regulation of endocytosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048268	clathrin coat assembly
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0061024	membrane organization
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
GO:2000370	positive regulation of clathrin-mediated endocytosis
GO:2000643	positive regulation of early endosome to late endosome transport
GO:2001046	positive regulation of integrin-mediated signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016324	apical plasma membrane
GO:0030132	clathrin coat of coated pit
GO:0030665	clathrin-coated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070022	transforming growth factor beta receptor homodimeric complex
GO:0070062	extracellular vesicular exosome