Version 5.4
Mus musculus Gene: Rpgrip1l
Summary
InnateDB Gene IDBG-179794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rpgrip1l
Gene Name Rpgrip1-like
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033282
Encoded Proteins
IDBP-179796
Rpgrip1-like
IDBP-538084
Rpgrip1-like
IDBP-533406
Rpgrip1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103494:
The protein encoded by this gene can localize to the basal body-centrosome complex or to primary cilia and centrosomes in ciliated cells. The encoded protein has been found to interact with nephrocystin-4. Defects in this gene are a cause of Joubert syndrome type 7 (JBTS7) and Meckel syndrome type 5 (MKS5). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:91217030-91313262
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000047783 ENSMUSP00000042702
ENSMUST00000139113 ENSMUSP00000118230
ENSMUST00000136198
ENSMUST00000132757 ENSMUSP00000120818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
GO:0031870 thromboxane A2 receptor binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001889 liver development
GO:0007163 establishment or maintenance of cell polarity
GO:0007368 determination of left/right symmetry
GO:0007420 brain development
GO:0008589 regulation of smoothened signaling pathway
GO:0021532 neural tube patterning
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0021670 lateral ventricle development
GO:0021772 olfactory bulb development
GO:0022038 corpus callosum development
GO:0022900 electron transport chain
GO:0035108 limb morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0042384 cilium assembly
GO:0043010 camera-type eye development
GO:0043584 nose development
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0060039 pericardium development
GO:0060271 cilium morphogenesis
GO:0060322 head development
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0005929 cilium
GO:0005930 axoneme
GO:0036064 ciliary basal body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103494
View Gene Order
ENSBTAG00000012499
Not yet available
Pathways
NETPATH
REACTOME
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8CG73
TrEMBL D3Z0V3 D6RIK9
UniProt Splice Variant
Entrez Gene 244585
UniGene Mm.324592 Mm.418185
RefSeq NM_173431 XM_006530991 XM_006530992 XM_006530995 XM_006530996
OMIM
CCDS CCDS22520
HPRD
IMGT
MGI ID MGI:1920563
MGI Symbol Rpgrip1l
EMBL AC139351 AJ344253 CH466525
GenPept CAC87257 EDL11076
RNA Seq Atlas 244585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca