Version 5.4
Mus musculus Gene: Cops8
Summary
InnateDB Gene IDBG-179989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cops8
Gene Name COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
Synonyms 9430009J09Rik; AA408242; Csn8; Sgn8
Species Mus musculus
Ensembl Gene ENSMUSG00000034432
Encoded Proteins
IDBP-179991
COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
IDBP-787952
COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
IDBP-787956
COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20074051
[Homo sapiens] COPS8 is part of the COP9 signallosome that functions to control NF-kappaB activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198612:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:90602981-90613341
Strand Forward strand
Band D
Transcripts
ENSMUST00000036153 ENSMUSP00000035884
ENSMUST00000191510
ENSMUST00000189309
ENSMUST00000190057
ENSMUST00000186152
ENSMUST00000186750 ENSMUSP00000139836
ENSMUST00000190700
ENSMUST00000189107
ENSMUST00000186882 ENSMUSP00000140707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008285 negative regulation of cell proliferation
GO:0010388 cullin deneddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198612
View Gene Order
ENSBTAG00000005854
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_133805 XM_006529064
OMIM
CCDS CCDS15153
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca