Version 5.4
Mus musculus Gene: Lalba
Summary
InnateDB Gene IDBG-180342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lalba
Gene Name lactalbumin, alpha
Synonyms AW208827
Species Mus musculus
Ensembl Gene ENSMUSG00000022991
Encoded Proteins
IDBP-180344
lactalbumin, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167531:
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:98480400-98482683
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000023726 ENSMUSP00000023726
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004461 lactose synthase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0005989 lactose biosynthetic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000167531
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu00052
Galactose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00052
Galactose metabolism pathway
INOH
INOH website
Galactose metabolism pathway
PID NCI
Cross-References
SwissProt P29752
TrEMBL
UniProt Splice Variant
Entrez Gene 16770
UniGene
RefSeq NM_010679 XM_006520517
OMIM
CCDS CCDS27795
HPRD
IMGT
MGI ID MGI:96742
MGI Symbol Lalba
EMBL BC006922 BC069916 M80909 M87863
GenPept AAA37208 AAA37209 AAH06922 AAH69916
RNA Seq Atlas 16770

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca